Calcium folinate calcium leucovorin is a potent agent for neutralizing the immediate toxic effects of methotrexate on the haematopoietic system.
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sulfonamides may increase the effect of oral anticoagulants, methotrexate, sulfonylureas, thiazide diuretics, phenytoin, and uricosuric agents.
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many different regimens exist; common combination regimens include methotrexate 20 mg m2 iv as a single dose with cisplatin, doxorubicin, and cyclophosphamide, every 28 days; methotrexate 40 mg m2 iv for one dose with etoposide and cisplatin; and methotrexate 100 mg m2 iv for one dose along with cyclophosphamide, vincristine, and doxorubicin.
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taking trexall if you have a deficiency in folic acid may increase the risk of methotrexate toxicity.
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when given po, methotrexate is 15-20 mg m2 day in maintenance.
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