Paroxetine in a study of the interaction between the selective serotonin reuptake inhibitor ssri paroxetine 20 mg day for two weeks and a single dose of maxalt rdp 10 mg in healthy subjects n 12 , neither the plasma concentrations of maxalt rdp nor its safety profile were affected by paroxetine.
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due to the narrow therapeutic index of pimozide and its known ability to prolong the qt interval, concomitant use of pimozide and paroxetine hydrochloride controlled-release tablets is contraindicated see contraindications .
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paroxetine may cause serious side effects, including all of those described in the section entitled what is the most important information i should know about paroxetine.
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table 2 enumerates adverse events that occurred at an incidence of 1 or more among paroxetine-treated patients who participated in short-term 6 week placebo-controlled trials in which patients were dosed in a range of 20 mg to 50 mg day.
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the extent to which these events may be associated with paroxetine hydrochloride controlled-release tablets is unknown.
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