In addition, olanzapine may block the dopamine agonist properties of apomorphine, thereby compromising apomorphine effectiveness.
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direct glucuronidation and cytochrome p450 mediated oxidation are the primary metabolic pathways for olanzapine.
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in a pre- and postnatal study conducted in rats, olanzapine and fluoxetine were orally administered during pregnancy and throughout lactation in combination at dose levels up to 2 olanzapine plus 4 fluoxetine mg kg day 1 and 0.
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due to the risk of additive qt prolongation and potential for serious arrhythmias, the concurrent use of olanzapine and thioridazine is considered contraindicated.
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