And here we go again on december 12, 2016, fda has concluded in a drug safety communication, referring to an updated fda-review of data indicating that there exist an increased risk of bladder cancer with pioglitazone-containing medicines, which currently include, in the us actos, actoplus met, actoplus met xr, duetact, and oseni.
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bioequivalence has been demonstrated between the fixed combination of immediate-release pioglitazone and immediate-release metformin hydrochloride actoplus met and each agent given concurrently as separate tablets at the currently approved dosage strengths 500 or 850 mg of metformin hydrochloride and 15 mg of pioglitazone , and between the fixed combination of immediate-release pioglitazone and extended-release metformin hydrochloride actoplus met xr and each agent given concurrently as separate tablets at the currently approved dosage strengths 1 g of metformin hydrochloride and 15 or 30 mg of pioglitazone .
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