Serious side effects of arava may include allergic reaction; blistering or peeling skin; blisters on the inside of eyes, nose, or mouth; chest pain; dark urine; easy bruising bleeding; feelings of numbness or tingling; fever; infection; muscle cramps; pale skin; pale stools; sore throat; stomach pain; unusual tiredness; vomiting; yellowing of the eyes or skin.
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the exact mechanisms of how arava suppresses the immune system is not fully understood.