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in previous drug metabolism studies in rats, colchicine has been shown to undergo extensive hepatic metabolism, and parent and metabolites are eliminated mainly by biliary excretion hunter and klaassen, 1975; sabouraud et al.
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formation of the gsh conjugate m1 suggests that colchicine biotransformation may proceed through an electrophilic intermediate.
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the psnr of colchicine reached 47 and the peaks of m1, m2, m3, and m4 were observed and resolved.
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