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Nitroprusside and hydralazine increase the renal clearance of digoxin by increasing renal blood flow and tubular secretion and lowering plasma digoxin levels.

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it appears that this interaction is mediated by ritonavir s inhibition or p-glycoprotein-mediated renal tubular secretion of digoxin.

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in such patients consideration should be given to the inser tion of a pacemaker before treatment with digoxin.

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we use a markov model to project life expectancy and lifetime medical care costs for a hypothetical cohort of patients with chf who were assumed alternatively to receive carvedilol plus conventional therapy digoxin, diuretics, and angiotensin-converting enzyme inhibitors or conventional therapy alone.

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