Serious, sometimes fatal, reactions with signs and symptoms including hyperthermia, rigidity, myoclonus, autonomic instability with rapid vital sign fluctuations, and mental status changes progressing to extreme agitation, delirium, and coma have been reported in patients receiving a combination of selective serotonin reuptake inhibitors ssris , including fluoxetine prozac , fluvoxamine luvox , sertraline zoloft , and paroxetine paxil and non-selective maois or the selective mao-b inhibitor selegiline.
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