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Adverse reactions not observed in clinical studies, but seen in animals at exposure levels similar to clinical exposure levels were as follows in repeated-dose toxicity studies histopathologic liver changes likely due to the pharmacologic action of rosuvastatin were observed in mouse, rat, and to a lesser extent with effects in the gall bladder in dogs, but not in monkeys.
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Rosuvastatin is a medicine that is both a selective and competitive inhibitor of hmg-coa reductase, which is the rate-limiting enzyme that converts coenzymes into mevalonate.
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moreover, it is highly soluble in water and is thus easy to remove during the subsequent formation of the rosuvastatin calcium rsvca salt of formula ii .