Cefixime works by destroying a layer of the cell wall of the bacteria, which causes the wall to break down.
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cefixime is administered orally and may be given without regard to meals.
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if cefixime is used in the treatment of infections caused by group a b-hemolytic streptococci, therapy should be continued for at least 10 days to decrease the risk of rheumatic fever or glomerulonephritis.
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transient increases in bun1, 2, 41, 74 and serum creatinine concentrations and acute renal failure have been reported in less than 2 of patients receiving cefixime.
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when the disk-diffusion susceptibility test is performed according to nccls standardized procedures using nccls interpretive criteria, enterobacteriaceae with growth inhibition zones of 19 mm or greater are susceptible to cefixime, those with zones of 16-18 mm be have intermediate susceptibility, and those with zones of 15 mm or less are resistant to the drug.
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