These are all unlikely with low-dose methotrexate.
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Store methotrexate at room temperature, between 68 and 77 degrees f 20 and 25 degrees c .
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A warning added in may 2012 cautions that using certain ppis with methotrexate, a drug commonly used to treat certain cancers, types of arthritis, and autoimmune conditions, can lead to elevated levels of methotrexate in the blood, causing toxic side effects.
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pubmed 11669456 takeda m, khamdang s, narikawa s, kimura h, hosoyamada m, cha sh, sekine t, endou h characterization of methotrexate transport and its drug interactions with human organic anion transporters.