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Dutas does not inhibit the in vitro metabolism of model substrates for the major human cytochrome p450 isoenzymes cyp1a2, cyp2c9, cyp2c19, cyp2d6, and cyp3a4 at a concentration of 1,000 ng ml, 25 times greater than steady-state serum concentrations in humans.
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One controlled trial suggests that among those with adhd and comorbid tics the combination of clonidine and methylphenidate is superior than either drug as a standalone treatment.
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For empiric therapy of acute, uncomplicated utis, co-trimoxazole, a fluoroquinolone, fosfomycin, nitrofurantoin, or an oral cephalosporin usually is recommended.
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